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KMID : 0043319930160010068
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Archives of Pharmacal Research
1993 Volume.16 No. 1 p.68 ~ p.70
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Synthesis of 2,5-Bis(2’’-piperidylmethyl)piperidine and Related Compounds
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Hammounda M
Kandeel ED/Hamama W/Afsah E
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Abstract
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The triketones 3-6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-Mannich base (1) or (2). Schmidt reaction of the tricketones 3-6 afforded the corresponding tricyclic lactames 7-10 respectively. Reduction of 7 and 9 gave compounds 11 and 12 respectively.
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KEYWORD
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